Ari Borthakur, Ph.D.
Assistant Professor, Department of Radiology
B1 Stelllar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104-6100
Tel:(215) 573-8482
Fax: (215) 573-2113
email: ari@mail.mmrrcc.upenn.edu
web: Borthakur web page
Education :
Ph.D. 2000, University of Pennsylvania (Biophysics)
Research Interests :
Develop novel spin-lock (or T1ρ) MRI applications
Perform quantitative studies via MR relaxometry
Implement multi-nuclear & multiple-quantum-filtered MRI capability on clinical scanners via: pulse sequence development
RF coil design and construction
The goal of our research is to develop non-invasive and non-destructive techniques for the study of Alzheimer’s Disease and Arthritis. We facilitate timely clinical diagnoses by inventing and improving MRI pulse sequences and hardware. Our multi-nuclear and relaxometric techniques are routinely applied in model systems as well as in clinical research. We maintain active partnerships with faculty from Pathology, Neurology, Orthopedic Surgery and Rheumatology departments and recruit doctoral candidates from Biophysics and Bioengineering graduate programs.
Professional Experience :
2004-present: Assistant Professor, Dept. of Radiology, University of Pennsylvania
2000-2004: Post-doctoral Researcher, Dept. of Radiology, University of Pennsylvania
1996-2000: Teaching Assistant, Dept. of Biophysics, University of Pennsylvania
1994-2000: Graduate Fellow, Dept. of Biophysics, University of Pennsylvania
Summer 1994: Research Assistant, Dept. of Radiology, University of Texas Medical School
Summer 1993: Intern, Dept. of Radiology, University of Texas Medical School
1992-1994: Lab Consultant, Microlab Facility, Angelo State University
Publications :
Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R. Sodium and T1ρ MRI for molecular and diagnostic imaging of articular cartilage (Review Article). NMR in Biomedicine 2006 (in press).
Borthakur A, Gur T, Wheaton AJ, Corbo M, Trojanowski JQ, Lee VM, Reddy R. In vivo Measurement of Plaque Burden in a Mouse Model of Alzheimer’s Disease. Journal of Magnetic Resonance Imaging 2006;24:1011-1017.
Auerbach JD, Johannessen W, Borthakur A, Wheaton AJ, Dolinskas CA, Balderston RA, Reddy R, Elliott DM. Quantitative in vivo Assessment of Human Lumbar Disc Degeneration Using T1ρ-weighted Magnetic Resonance Imaging. European Spine Journal 2006;15:338-344.
Borthakur A, Hulvershorn J, Gualtieri E, Wheaton AJ, Charagundla S, Elliott MA, Reddy R. A pulse sequence for rapid in vivo spin-locked MRI. J Magn Reson Imaging 2006;23(4):591-596.
Hulvershorn J, Borthakur A, Bloy L, Gualtieri EE, Reddy R, Leigh JS, Elliott MA. T1ρ contrast in functional magnetic resonance imaging. Magnetic Resonance in Medicine 2005;54(5):1155-1162.
Wheaton AJ, Dodge GR, Borthakur A, Kneeland JB, Schumacher HR, Reddy R. Detection of changes in articular cartilage proteoglycan by T1ρ magnetic resonance imaging. Journal of Orthopedic Research 2005; 23:102-108.
Gougoutas AJ, Wheaton AJ, Borthakur A, Shapiro EM, Kneeland JB, Udupa JK, Reddy R. Cartilage volume quantification via Live Wire segmentation. Academic Radiology 2004; 11:1389-1395.
Wheaton AJ, Borthakur A, Corbo MT, Moonis G, Melhem E, Reddy R. T2ρ-weighted contrast in MR images of the human brain. Magnetic Resonance in Medicine 2004; 52:1223-1227.
Borthakur A, Wheaton AJ, Gougoutas AJ, Akella SVS, Regatte RR, Charagundla SR, Reddy R. In vivo measurement of T1rho dispersion in the human brain at 1.5T. Journal of Magnetic Resonance Imaging 2004; 19:403-409.
Borthakur A, Charagundla SR, Wheaton AJ, Reddy R. T1ρ-weighted MR imaging using a surface coil to transmit spin-lock pulses. Journal of Magnetic Resonance 2004; 167:306-316.
Wheaton AJ, Borthakur A, Reddy R. Application of keyhole technique to T1ρ relaxation parameter mapping. Journal of Magnetic Resonance Imaging 2003; 18:745-749.
Charagundla SR, Borthakur A, Leigh JS, Reddy R. Artifacts in T1ρ-weighted imaging: correction with a self-compensating spin-locking pulse. Journal of Magnetic Resonance 2003; 162(1):113-121.
Borthakur A, Shapiro EM, Akella SVS, Gougoutas A, Kneeland JB, Reddy R. Quantifying sodium in the human wrist in vivo by using MR imaging. Radiology 2002; 242:598-602.
Shapiro EM, Borthakur A, Shapiro MJ, Reddy R, Leigh JS. Fast MRI of RF heating via phase difference mapping. Magnetic Resonance in Medicine 2002; 47(3):492-498.
Shapiro EM, Borthakur A, Gougoutas A, Reddy R. 23Na MRI accurately measures FCD in articular cartilage. Magnetic Resonance in Medicine 2002; 47(2):284-291.
Borthakur A, Hancu I, Boada FE, Shen GX, Shapiro EM, Reddy R. In vivo triple quantum filtered twisted projection sodium MRI of human articular cartilage. Journal of Magnetic Resonance 1999; 141(2):286-290.
Narayana PA, Borthakur A. Effect of radio frequency inhomogeneity correction on the reproducibility of intra-cranial volumes using MR image data. Magnetic Resonance in Medicine 1995; 33(3):396-400.