M.D. & Ph.D. Candidate, Biochemistry and Molecular Biophysics Graduate Group

Full CV available for Download

Contact

B1 Stellar-Chance Laboratories

422 Curie Blvd., University of Pennsylvania

Philadelphia PA 19104-6100

Tel: 215-898-9357

Fax: 215-573-2113

email: emellon@mail.med.upenn.edu

Education

B.A., Biology and Psychology, University of Delaware, 2002

Recent Work

Research Interests

My interests center on the development of MR technology towards the study of the brain. While my thesis project uses 17-Oxygen in pigs to assess cerebral metabolism, I maintain part-time projects in the areas of human high-resolution brain imaging, multinuclear brain imaging mostly involving 17O and 23Na, and fast imaging techniques to study the effects of 16Oxygen and other in vivo contrast agents.

As a member of the Reddy lab, I also contribute to projects related to musculoskeletal imaging. While I mainly play an assistive role in these projects, I like to think about novel ways to apply MR to ex vivo studies of tissues such as cartilage.

Professional Experience

Summer 2002 - Summer 2003: Research Assistant Department of Neuroscience, DuPont Hospital for Children, Wilmington, DE 2000-2002: Research Assistant Neuromorphic Systems Laboratory, University of Delaware, Newark DE

Related Experience

1997-2000: Systems Administrator Access 2000, West Chester, PA

Publications

Mellon EA, Beesam RS, Baumgardner JE, Borthakur A, Witschey WR 2nd, Reddy R (2008) Estimation of the cerebral metabolic rate of oxygen consumption with proton detected 17O MRI during precision 17O2 inhalation in swine. Journal of Magnetic Resonance Imaging. Submitted.

Mellon EA, Pilkinton DT, Clark CM, Elliott MA, Witschey WR 2nd, Reddy R, Borthakur A (2008) Sodium MRI detection of mild Alzheimer Disease. Magnetic Resonance in Medicine. In review.

Mellon EA, Borthakur A, Elliott MA, Witchey W, Wang C, Reddy R (2007) Single shot T1ρ magnetic resonance imaging of metabolically generated water in vivo. Adv Exp Med Biol. In press.

Baumgardner JE, Mellon E, Tailor D, Kasam M, Borthakur A, Reddy R (2007) Pulsed inhalation of 17O2 for NMR imaging of cerebral metabolism. IEEE-TBME. In review.

Borthakur A, Mellon E, Niyogi S, Witchey W, Kneeland JB, Reddy R (2006) Sodium and T1ρ MRI for the molecular and diagnostic imaging of articular cartilage. NMR in Biomed 19:781-821.

Chang JH, Mellon E, Schanen NC, Twiss JL (2003) Persistent TrkA activity is necessary to maintain transcription in neuronally differentiated PC12 cells. J Biol Chem 278:42877-42885.