<-Main TR&D Page
Overview
Lab Members
Mitchell Schnall / Rahim Rizi / Hee Kwon Song / Masaru Ishii / Kiarash Emami / Ze Wang / Jeremy Magland / Larry Dougherty / Angela Haczku / James Crapo / Kwaku Ohene-Frempong / Milton Rossman
About the Core
| This TR&D project focuses on the development of novel dynamic MR imaging methods focusing on radial k-space sampling. TR&D 3 includes 2 subprojects. The first subproject consists of implementation of radial sampling with time-filtered reconstruction for dynamic contrast enhanced MRI. This work will be extended to include novel approaches to motion compensation in order to address the compelling problem of acquiring DCE-MRI data in the setting of respiratory motion. This work is driven by the compelling need for a robust DCE-MRI method for generalized implementation in early phase studies of angiogenesis targeted cancer treatment. Example studies under development and implantation by ACRIN are described as driving projects in this application, however they serve as a single example of the need for this technology.
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| The second subproject focuses on the development of radial sampling methods to acquire dynamic hyperpolarized 3He images of lung ventilation. This effort is motivated by the high temporal resolution required to study forced expiration, which is critical to assessing obstructive lung diseases. The radial approach also has the unique feature of high SNR per pulse applied due to the view sharing used in reconstruction, which allows preservation of hyperpolarized magnetization for high frame rates of acquisition. The radial approach inherently requires less number of views to construct each frame, which allows for a more efficient use of the unrecoverable magnetization of the hyperpolarized nuclei. This property can be either used to acquire a larger number of frames at higher temporal resolution, or to increase the achievable SNR without sacrificing the number of acquired images.
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Active Research
Last modified February 2, 2009 8:11 pm /
