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Sadly, Dr. Leigh passed away on March 10, 2008. [Jack's Obituary]

Britton Chance Professor of Radiology

Founding Director, CMROI


Contents

Education

BSc, 1961 University of Pennsylvania (Electrical Engineering)

PhD, 1971 University of Pennsylvania (Biophysics)

Recent Work

Research Interests

To develop innovative magnetic resonance (MR) and optical technologies for biomedical research. Many of these technologies are driven by both basic and clinical research collaborators in the biomedical field to address specific clinical problems and to further fundamental understanding of biophysical, physiological, structural, and functional properties of biological systems in vivo.

To investigate the use of multinuclear MR techniques to study the structural and metabolic properties of cartilage, brain, and muscle, with direct application to osteoarthritis, cognitive funtion, and muscular dystrophy.

To investigate the use of multinuclear MR to monitor, the efficacy of gene therapy and gene expression in general.

To develop and improve quantitative perfusion and diffusion imaging, in comparison to PET.

To develop innovative techniques for quantitative structural imaging of multiple organ systems. These techniques include MR of hyperpolarized gases, novel contrast generation using zero-quantum coherences, and imaging of tissue microstructure.

To focus on combining optical and MR imaging techniques for the study of neurophysiology, peripheral vascular disease, and breast cancer.


Honors and Awards

1967-1969 NIH Predoctoral Fellow

1974-1975 Guggenheim Fellow, University of Cambridge

1975-1980 NIH, Research Career Development Award

1999 Fellow, International Society of Magnetic Resonance in Medicine

Teaching Interests

Graduate level Biological Magnetic Resonance Courses

Publications

  • Liu CS, Miki A, Hulvershorn J, Bloy L, Gualtieri EE, Liu GT, Leigh JS, Haselgrove JC, Elliott MA. Spatial and Temporal Characteristics of Physiological Noise in fMRI at 3T. Acad Radiol 2006;13(3):313-323.
  • Dimitrov, I.E., Insko, E., Rizi, R., Leigh, J.S. 'Indirect detection of lung perfusion using susceptibility-based hyperpolarized gas imaging', Journal of Magnetic Resonance Imaging 21(2): 149-55 (2005).
  • Hulvershorn, J., Bloy, L., Gualtieri, E.E., Redmann, C.P., Leigh, J.S., Elliott, M.A. 'Temporal resolving power of spin echo and gradient echo fMRI at 3T with apparent diffusion coefficient compartmentalization', Human Brain Mapping 25(2): 247-58 (2005).
  • Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M.A. 'Spatial sensitivity and temporal response of spin echo and gradient echo bold contrast at 3 T using peak hemodynamic activation time', Neuroimage 24(1): 216-23 (2005).
  • Hulvershorn J, Borthakur A, Bloy L, Gualtieri EE, Reddy R, Leigh JS, Elliott MA. T1rho contrast in functional magnetic resonance imaging. Magn Reson Med 2005;54(5):1155-1162.
  • Mawn T, Nioka S, Nijland M, Bloy L, Elliott MA, Chance B, Leigh JS. Effect of errors in baseline optical properties on accuracy of transabdominal near-infrared spectroscopy in fetal sheep brain during hypoxic stress. J Biomed Opt 2005;10(6):64001.
  • Li L, Leigh JS. Quantifying arbitrary magnetic susceptibility distributions with MR. Magn Reson Med 2004;51(5):1077-1082.
  • McCully KK, Smith S, Rajaei S, Leigh JS, Jr., Natelson BH. Muscle metabolism with blood flow restriction in chronic fatigue syndrome. J Appl Physiol 2004;96(3):871-878.
  • Tailor DR, Baumgardner JE, Regatte RR, Leigh JS, Reddy R. Proton MRI of metabolically produced H2 17O using an efficient 17O2 delivery system. Neuroimage 2004;22(2):611-618.
  • Dimitrov, I.E., Insko, E., Rizi, R., Leigh, J.S. 'Indirect detection of lung perfusion using susceptibility-based hyperpolarized gas imaging" Journal of Magnetic Resonance Imaging 21(2): 149-55 (2005).
  • Hulvershorn, J., Bloy, L., Gualtieri, E.E., Redmann, C.P., Leigh, J.S., Elliott, M.A. 'Temporal resolving power of spin echo and gradient echo fMRI at 3T with apparent diffusion coefficient compartmentalization." Human Brain Mapping 25(2): 247-58 (2005).
  • Tailor DR, Roy A, Regatte RR, Charagundla SR, McLaughlin AC, Leigh JS, and Reddy R (2003) "Indirect 17O-Magnetic Resonance Imaging of Cerebral Blood Flow in Rat" Magnetic Resonance in Medicine 49(3):479-87.
  • Tailor DR, Poptani H, Glickson JD, Leigh JS, and Reddy R (2003) "High-Resolution Assessment of Blood Flow in Murine RIF-1 Tumors by Monitoring Uptake of H217O with Proton T1ρDispersion Imaging." Magnetic Resonance in Medicine 49(1):1-6.
  • Shapiro, E.M., Borthakur, A., Shapiro, M.J., Reddy, R., Leigh, J.S. (2002) "Fast MRI of RF Heating Via Phase Difference Mapping." Magnetic Resonance in Medicine 47(3):492-8.
  • Roberts, D.A., Rosen, M.A., Clarc T.W., Mondschein, J., Soulen, M.C., Siegelman E., Leigh, J.S. Jr. (2002) "Chemical-shift MR imaging of acetic acid during percutaneous chemical ablation therapy: preliminary work." Journal of Vascular & Interventional Radiology 13(10):1055-1059.
  • Duvvuri, U., Kudchodkar, S., Reddy R., Leigh, J.S. (2002) "T1ρ relaxation can assess longitudinal proteoglycan loss from articular cartilage in vitro." Osteoarthritis & Cartilage 10(11): 838-44.
  • Shapiro, E.M., Borthakur, A., Shapiro, M.J., Reddy, R., Leigh, J.S. (2002) "Fast MRI of RF Heating Via Phase Difference Mapping." Magnetic Resonance in Medicine 47(3):492-8.
  • Lipson, D.A., Roberts, D.A., Hansen-Flaschen, J., Gentile, T.R., Jones, G., Thompson, A., Dimitrov, I.E., Palevsky, H., Leigh, J.S., Schnall, M.D., Rizi, R. (2002) "Pulmonary Ventilation And Perfusion Scanning Using Hyperpolairized Helium-3 MRI And Arterial Spin-Tagging In Healthy Subjects in Pulmonary Embolism, And In Orthotopic Lung Transplant Recipients." Magnetic Resonance Med. 47(6): 1073-74.
  • Shapiro, E.M., Borthakur, A., Kaufman, J., Leigh, J.S., and Reddy, R. (2001) "Water Distribution Patterns Inside Bovine Articular Cartilage as Visualized by 1H Magnetic Resonance Imaging." Osteoarthritis and Cartilage 9(6):533-8.
  • Roberts, D. A., Rizi, R. R., Lipson, D. A., Aranda, M., Bearn, L., Rolf, L., Baumgardner, J., Hatabu, H. H., Hansen-Flaschen, J., Gefter, W. B., Leigh, J. S., and Schnall, M. D. (2001) "Dynamic Observation of Pulmonary Perfusion using Continuous Arterial Spin-labeling in a Pig Model." J. Magn. Reson. Imag. 14(2):175-80.
  • Poptani, H., Duvvuri, U, Mancuso, A., Frazier, N., Leigh, J.S., Glickson, J., and Reddy, R. (2001) "T1ρ Imaging of Murine Brain Tumors." Academic Radiology 8(1):42-7 (2001).
  • Li, L., Shapiro, E., and Leigh, J.S. (2001) "Significant Precision Improvement for Temperature Mapping." Magn. Res. In Med. (Communications) 46:678-682.
  • Li, L. and Leigh, J.S. (2001) "High-Precision Mapping of the Magnetic Field Utilizing the harmonic Function Mean Value Property." Journal of Magnetic Resonance 148:442-448.
  • Hoydu, A., Kitano, Y., Kriss, A., Hensley, H., Bergey, P., Flake, A., Hubbard, A., and Leigh, J.S. (2001) "In vivo, In utero Microscopic Magnetic Resonance Imaging: Application in a Rat Model of Diaphragmatic Hernia." Magnetic Resonance in Medicine 44(2):331-5.
  • Duvvuri U., Goldberg, A.D., Kranz, J.K., Hoang, L., Reddy, R., Wehrli, F.W., Wang, A.J., Englander, S.W., Leigh, J.S. (2001) "Water Magnetic Relaxation Dispersion In Biological Systems: The Contribution Of Proton Exchange And Implications For The Noninvasive Detection Of Cartilage Degradation." Proceedings of the National Academy of Sciences of the United States of America 98(22):12479-84.
  • Duvvuri, U., Charagundla, S.R., Kudchodkar, S B., Kaufman, J.H., Kneeland, J.B., Rizi, R., Leigh, J.S. and Reddy, R. (2001) In vivo Tρ Weighted Imaging Of The Human Knee At 1.5T: Preliminary Experience." Radiology 220(3):822-6.
  • Duvvuri, U., Poptani, H., Feldman, M., Nadal-Desbarats, L., Gee, M., Lee, W., Reddy, R., Leigh, J.S., and Glickson, J.D. (2001) Quantitative T1ρ Magnetic Resonance Imaging of RIF-1 Tumors in vivo: Detection of Early Response to Cyclophosphamide Therapy." Cancer Research 61:7747-7753.
  • Duvvuri, U., Kudchodkar, S.K., Leigh, J.S. & Reddy, R. (2001) "A Novel Magnetic Resonance Imaging Method for Assessing Cartilage Integrity." Osteoarthritis & Cartilage 8:Suppl. B, S10 2001.
  • Dimitrov, I.E., Reddy, R., and Leigh, J.S. (2001) "Intermolecular Dipole-Dipole Relaxation of (129) Xe Dissolved in Water." Journal of Magnetic Resonance 145(2): 302-6.
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