Assistant Professor, Department of Radiology

Associate Director (Collaboration and Service), CMROI

Contact

B1 Stellar-Chance Laboratories

422 Curie Blvd., University of Pennsylvania

Philadelphia PA 19104-6100

Tel: 215-898-9357

Fax: 215-573-2113

email: mark@mail.mmrrcc.upenn.edu

web: Mark's homepage

Education

BSE, 1984 University of Pennsylvania (Electrical Engineering)

PhD, 2000 University of Pennsylvania (Biophysics)

Recent Work

Research Interests

The primary focus of my research is the investigation of neuronal activity through the combined use of functional magnetic resonance imaging (fMRI) and near-infrared spectroscopy (NIRS). These two modalities provide complimentary spatial and temporal measurement of brain blood oxygenation changes during neuro-cognitive activity. The lab is focused on primary technique and analysis development, including the design of new infrared probes and MR pulse sequences. This field spans the areas of MR physics, optics, medical imaging , signal processing, and biostatistics.

Professional Experience

• 2001- present: Assistant Professor, Dept. of Radiology, University of Pennsylvania, Philadelphia PA
• 2000 - 2001: Research Associate, Dept. of Radiology, University of Pennsylvania
• 1996 - 2000: Technical Director, MMRRCC, University of Pennsylvania
• 1992 - 1995: Director of Computing, MMRRCC, University of Pennsylvania
• 1990 - 1991: Staff Research Assistant, Dept. of Radiology, University of California, San Francisco, CA
• 1988 - 1989: Instructor, Woods Hole Education Authority, Woods Hole, MA
• 1986 - 1988: System Manager, Dept. of Biophysics, University of Pennsylvania
• 1984 - 1985: Engineer, General Electric Co. Space Systems Division, Valley Forge, PA

Publications

• Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M.A. 'Spatial sensitivity and temporal response of spin echo and gradient echo bold contrast at 3 T using peak hemodynamic activation time', Neuroimage 24(1): 216-23 (2005).

• Hulvershorn, J., Bloy, L., Gualtieri, E.E., Redmann, C.P., Leigh, J.S., Elliott, M.A. 'Temporal resolving power of spin echo and gradient echo fMRI at 3T with apparent diffusion coefficient compartmentalization', Human Brain Mapping 25(2): 247-58 (2005).

• Elliott M.A., EE Gualtieri, J Hulvershorn, JD Ragland, R Gur, (2004) "The Effects of Geometric Distortion Correction on Motion Realignment in fMRI" Academic Radiology, Acad Radiol. 2004 Sep;11(9):1005-10.

• Ragland, J.D., Gur, R.C., Valdez, J., Turetsky, B.I., Elliott, M.A., Kohler, C., Siegel, S., Kanes, S., Gur, R.E.(2004) "Event-Related fMRI of Frontotemporal Activity During Word Encoding And Recognition in Schizophrenia" American Journal of Psychiatry, 161,1004-1015.

• Hulvershorn J, Bloy L, Leigh JS, Elliott MA, (2003) "Continuous wave optical spectroscopic system for use in magnetic resonance imaging scanners for the measurement of changes in hemoglobin oxygenation states in humans" Rev. Sci. Instrum. 74, 4150.

• Insko EK, Clayton DB, Elliott MA (2002) "In vivo sodium imaging of the intervertebral disk at 4T" Academic Radiology, 9:800-804.

• Russ DW, Vandenborne K, Walter GA, Elliott M.A., Binder-Macleod SA. (2002) "Effects of muscle activation on fatigue and metabolism in human skeletal muscle." Journal of Applied Physiology 92:1978-1986.

• Russ DW, Elliott MA, Vandenborne K, Walter GA, Binder-Macleod SA. (2002) "Metabolic costs of isometric force generation and maintenance of human skeletal muscle." American Journal of Physiology Endocrinology & Metabolism. 282(2):E448-E457.

• Clayton, D.B., Elliott, M.A., & Lenkinski, R.E. (2001) "In vivo protein spectroscopy without solvent suppression." Concepts in Magnetic Resonance 13(4):260-275.

• Vandenborne, K., Walter, G., Ploutz-Snyder, L., Dudley, G., Elliott, M.A., DeMeirleir, K. & Leigh, J.S. (2000) "Relationship between muscle T2 relaxatoin properties and metabolic state: a combined localized 31P spectroscopy and 1H imaging study." European Journal of Applied Physiology and Occupational Physiology 82:76-82.

• Shaffer, M., Okereke, E., Esterhai, J., Elliott, M.A., Walter, G., Yim, S. & Vandenborne, K. (2000) "The effects of immobilization on plantar flexion strength, endurance and fnuctional ability following an ankle fracture." Physical Therapy 80:769-780.

• Walter, G., Vandenborne, K., Elliott, M.A. & Leigh, J.S. (1999) "In vivo ATP systhesis rates in single human muscles during high intensity exercise." Journal of Physiology (London) 519:901-910.

• Elliott, M.A., Walter, G.A., Swift, A., Vandenborne, K., Schotland, J.C. & Leigh, J.S. (1999) "Spectral quantitation by principal component analysis using complex singular value decomposition." Magn Reson Med 41:450-455 (1999).

• Vandenborne, K., Elliott, M.A., Walter, G.A., Abdus, S., Okereke, E., Shaffer, M., Tahernia, D. & Esterhai, J.L. (1998) "Longitudinal study of skeletal muscle adaptations during immobilization and rehabilitation." Muscle & Nerve 21:1006-1012.

• Insko, E.K., Elliott, M.A., Schotland, J.C. & Leigh, J.S. "Generalized reciprocity." J Magn Reson 131:111-117.

• Greenman, R.L., Elliott, M.A., Vandenborne, K., Schnall, M.D. & Lenkinski, R.E. (1998) "Fast imaging of phosphocreatine using a RARE pulse sequence." Magnetic Resonance in Medicine 39:851-854.

• Elliott, M.A., Insko, E.K., Greenman, R.L. & Leigh, J.S. (1998) "Improved resolution and signal-to-noise ratio in MRI via enhanced signal digitization." Journal of Magnetic Resonance 130:300-304.

• Elliott, M.A., Walter, G.A., Gulish, H., Sadi, A.S., Lawson, D.D., Jaffe, W., Insko, E.K., Leigh, J.S. & Vandenborne, K. (1997) "Volumetric measurement of human calf muscle from magnetic resonance imaging." Magma 5:93-98.

• Haselgrove, J. & Elliott, M.A. (1991) "Peak assignment in automatic data analysis." Magn Reson Med 17:496-508.