CMROI, Department of Radiology

Contact

B1 Stellar-Chance Laboratories 422 Curie Blvd. Philadelphia, PA 19104-6100 Tel:(215) 510-8169 Fax: (215) 573-2113 email: harissgpgi@gmail.com

Education

B.Sc. DDU Gorakhpur University, India; M.Sc. Dr. RML Avadh University, India; Ph.D. Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

Work

Research Interests

-Develop novel spin-lock (or T1ρ) MRI applications

-Perfusion (DCE and DSC) MRI

The goal of our research is to develop non-invasive and non-destructive MRI techniques for the study of degenerative diseases such as Alzheimer’s Disease and Degenerative Disc Disease. We facilitate timely clinical diagnoses by inventing and improving MRI pulse sequences and hardware. Our multi-nuclear and relaxometric techniques are routinely applied in model systems as well as in clinical research. We maintain active partnerships with faculty from Pathology, Neurology, Orthopedic Surgery and Rheumatology departments and train doctoral candidates from Biophysics and Bioengineering graduate programs at the University of Pennsylvania.

Selected Publications

Gupta RK, Saksena S, Hasan KM, Agarwal A, Haris M, Pandey CM, Narayana PA. Focal Wallerian Degeneration of Corpus Callosum in Large Middle Cerebral Artery Stroke: Serial Diffusion Tensor Imaging. Journal of Magn Reson Imaging 2006 Aug 3;24(3):549-555.

Haris M, Gupta RK, Husain N, Hasan KM, Husain M, Narayana PA. Measurement of DTI metrics in hemorrhagic brain lesions: Possible implication in MRI interpretation. J Magn Reson Imaging 2006;24(6):1259-68.

Srivastava AK, Gupta RK, Haris M, Ray M, Kalita J, Misra UK. Cerebral venus-cynus thrombosis: developing and animal model. J of Neuroscience method 2007;161(2):220-222.

Pauliah M, Saxena V, Haris M, Husain N, Rathore RKS, Gupta RK. Improved T1-Weighted Dynamic Contrast Enhanced MRI to Probe Microvascularity and Heterogeneity of Human Glioma. Magn Reson Imaging 2007;25:1292-1299.

Gupta RK, Haris M, Husain N, Husain M, Prasad KN, Pauliah M, Srivastava C, Tripathi M, Rastogi M, Behari S, Singh A, Rathore D, Rathore RKS. Relative Cerebral Blood Volume is a Measure of Angiogenesis in Brain Tuberculoma and Its Therapeutic Implications. Journal of Computed Assisted Tomography (2007;31:335-341).

Singh A, Haris M, Rathore DKS, Purwar A, Sarma MK, Bayu G, Husain N, Rathore RKS, Gupta RK. Quantification of physiological and hemodynamic indices using T1 dynamic contrast enhanced MRI in intracranial mass lesions. J Magn Reson Imaging 2007;26:871-880.

Husain N, Awasthi S, Haris M, Gupta RK, Husain M. Vascular endothelial growth factor as a marker of Disease activity in CNS tuberculosis. J Infect 2008;56:114-119.

Haris M, Gupta RK, Husain M, Srivastava C, Singh A, Rathore RKS, Saksena S, Behari S, Husain N, Pandey CM, Prasad KN. Assessment of Therapeutic Response on Serial Dynamic Contrast Enhanced MR Imaging in Brain Tuberculomas. Clinical Radiol 2008;63:562-574.

Haris M, Gupta RK, Singh A, Rathore DS, Husain N, Husain M, Pandey CM, Srivastava C, Behari S, Singhal U, Rathore RKS. Differentiation of Infective from Neoplastic Brain Lesions by Dynamic Contrast Enhanced MRI. Neuroradiology 2008 2008 Jun;50(6):531-40.

Singh I, Haris M, Husain M, Husain N, Gupta RK. Role of Endoscopic Third Ventriculostomy in Patients with communicating Hydrocephalus-An Evaluation by MR Ventriculography. Neurosurgical Review Neurosurg Rev. 2008 Jul;31(3):319-25.

Haris M, Kumar S, Raj MK, Das KJM, Sapru S, Rathore RKS, Gupta RK. Serial Diffusion Tensor Imaging to Characterize Radiation Induced Changes in Normal Appearing White Matter following Radiotherapy in Patients with Adult Low Grade Gliomas. Radiation Medicine Radiat Med. 2008 Apr;26(3):140-50.

Gupta RK, Haris M, Husain N, Saksena S, Husain M, Rathore RKS. DTI derived indices correlate with immunohistochemistry obtained matrix metalloproteinase (MMP-9) expression in cellular fraction of brain tuberculoma. J Neurol Sci. 2008 Dec 15;275(1-2):78-85. Epub 2008 Aug 30.

Haris M, Husain N, Singh A, Awasthi R, Rathore RKS, Husain M, Gupta RK. Dynamic Contrast Enhanced (DCE) Derived Transfer coefficient (ktrans) is a Surrogate Marker of Matrix Metalloproteinase 9 (MMP-9) Expression in Brain Tuberculomas. J Magn Reson Imaging 2008;28:588-97.

Haris M, Husain N, Singh A, Husain M, Srivastava S, Srivastava C, Behari S, Rathore RKS, Saksena S, Gupta RK. Dynamic contrast enhanced derived cerebral blood volume correlates better with leak correction than with no correction for vascular endothelial growth factor, micro vascular density and grading of astrocytoma. J Comput Assist Tomogr. 2008 Nov-Dec;32(6):955-65

Singh A, Rathore RKS, Haris M, Husain N, Gupta RK. Improved bolus arrival time and arterial input function estimation for tracer kinetic analysis in DCE MRI. J Magn Reson Imaging. 2009 Jan;29(1):166-76

Kumar R, Husain M, Gupta RK, Hasan KM, Haris M, Agarwal A, Narayana PA. Serial Changes in the white matter Diffusion Tensor Imaging (DTI) Metrics in Moderate Traumatic Brain Injury and Correlation with Neuro-cognitive Functions. J Neurotrauma 2009(in press).

Haris M, McArdle E, Fenty M, Singh A, Davatzikos C, Trojanowski JQ, Melhem ER, Clark CM, Borthakur A. Early detection of Alzheimer’s disease: hippocampus T1rho estimation. J Magn Reson Imaging (in press)