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Contents |
Overview
Principal Investigator
Prof. Arjun G. Yodh Bio
Dr. Yodh's biomedical optics group page
Collaborators
| Prof. Britton Chance | Bio |
| Prof. John Detre | Bio |
| Prof. Turgut Durduran | Web Page |
| Prof. Mark Rosen | Bio |
| Prof. John Schotland | Bio |
| Prof. JiongJiong Wang | Web Page |
Lab Members
| Dr. Regine Choe | |
| Dr. Saurav Pathak | |
| David Busch | Web Page |
| Han Ban |
Selected Publications with other CMROI Cores
| Simultaneous Optical and MRI Imaging of Breast Cancer | Ntziachristos, Yodh, Schnall, Chance | PNAS, 2000 Neoplasia, 2001 |
| Experimental Validation of Analytical Inversion Techniques in Diffuse Optical Tomography | Konecky, Panasyuk, Lee, Markel, Yodh, Schotland | Optics Express, 2008 |
| Lesion Diagnosis with Stand-Alone, Parallel Plate, Diffuse Optical Tomography | Choe, Konecky, Corlu, Lee, Durduran, Busch, Czerniecki, Tchou, Fraker, DeMichele, Chance, Arridge, Schweiger, Culver, Schnall, Putt, Rosen, Yodh | JBO 2009 |
| Validation of Diffuse Correlation Spectroscopy with ASL-MRI | Yu, Floyd, Durduran, Zhou, Wang, Detre, Yodh | Optics Express, 2007 |
About the Core
Our objective is to develop innovative optical imaging technologies, optimal strategies for integrated optical and MRI methods, and theoretical algorithms required for high-resolution diffuse optical image reconstruction. Working closely with collaborators, the technologies we are working to develop will be used to diagnose cancer and gain detailed understanding of cancer metabolism, brain and muscle function under different pathophysiological conditions.
Active Research Projects
Simultaneous Optical and MR Cancer Imaging
This project focuses on expanding and improving our instrumentation and techniques for simultaneous acquisition of 3D diffuse optical and MR images, focusing on breast cancer. The system currently under development will utilize time resolved spectroscopy (TRS) to obtain absolution optical property maps (64 sources, 32 detectors, 6 wavelengths) and continuous wave (CW) measurements to obtain more spatial information and track contrast agent kinetics (64 sources, 256 detectors, 6 wavelengths), as well as permit fluorescence measurements.
High-Information Content Diffuse Optical Tomography
The goal of the proposed research is to construct an instrument for diffuse optical tomography and diffuse correlation tomography, primarily for phantom and small animal imaging. Independent source and detector scanning heads will allow an arbitrary number of source-detector combinations. The system is designed around a pulsed super-continuum laser source, allowing simultaneous acquisition of time domain data in up to 16 spectral windows. This system will allow expansion of our work developing substantially improved image reconstruction algorithms for optical tomography. Specifically, we are interested in 'analytical inversion' techniques, which allow high speed/low memory reconstruction of data sets with many (>10^4) source-detector pairs.
Systematic Investigation of Systematic Errors in Hand-Held Diffuse Optical Probes
Much of the work in diffuse optics has been conducted with inexpensive, convenient, and simple hand-held probes. With this work, we will develop an understanding of the systematic errors associated with these probes for tissue monitoring. The ease of use of the optical method, for example its ability for frequent, repeated measurements of blood oxygenation and blood flow, make it attractive for many applications in monitoring and treatment optimization. We are especially interested in long-term monitoring studies combining diffuse optical and established clinical techniques.
