Professor, Department of Radiology Director, MMRRCC

Contact

Tel: 215-898-5708

Fax: 215-573-2113

email: ravi@mail.mmrrcc.upenn.edu

Education

Ph.D. 1989, Indian Institute of Technology, Kanpur (Chemistry)

Recent Work

Research Interests

My research interests are In developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for early diagnosis and quantification of physiological and functional parameters in pathologies such as arthritis, stroke, cancer and Alzheimer’s Disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection and spin locking for studying molecular dynamics in biological tissues in vivo. In particular, sodium and spin-locking MRI are targeting to map proteoglycan molecules (e.g. Aggrecan) in the connective tissues in vivo. Indirect 17O MRI is aimed at studying cerebral blood flow and cerebral oxidative metabolism and tumor perfusion and metabolism. Spin-locking MRI is being developed to impart novel contrast in various tissue types (brain, connective tissues and tumors), macromolecular ordering in tissues, and visualize and quantify Amyloidal plaques in Alzheimer’s disease in vivo.

Teaching Interests

Co-director of two graduate level courses (BMB 601 and BMB 603) offered by the Biochemistry and Molecular Biophysics graduate group of the Biomedical Graduate Studies program of the University of Pennsylvania School of Medicine.

Research Support

These research activities are being supported by multiple NIH grants from NIAMS, NIBIB, NINDS, NCRR, NCI, the Arthritis foundation, the Whitaker foundation, the Dana Foundation, GSK, the University Research Foundation, and the McCabe foundation.

Dr. Reddy is the director of the Laboratory for Multinuclear Magnetic Resonance Imaging. Visit the Lab's website for more details about its research activities, recent developments, memebers, and a list of publications.

Publications