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Professor, Department of Radiology, Director, CMROI

Contents

Contact

Tel: 215-898-5708

Fax: 215-573-2113

email: krr@upenn.edu

Education

Ph.D. 1989 Indian Institute of Technology, Kanpur (Chemistry)
M.Sc. 1982 Kakatiya University, Warangal (Chemistry)
B.Sc. 1979 Osmania University, Hyderabad (Chemistry)

Positions and Employment

1988-1989 Research Assistant IIT, Kanpur
1989-1992 Post-Doctoral Fellow Dept. of Biochem/Biophysics UPenn
1992-1993 Research Associate Dept. of Radiology UPenn
1993-1995 Technical Director MMRRCC UPenn
1994-2000 Research Assist. Professor Dept. of Radiology UPenn
2000-2006 Associate Prof. of Radiology Dept. of Radiology UPenn
2006- Prof. of Radiology Dept. of Radiology UPenn
2007- Director, CMROI Dept. of Radiology UPenn

Professional Memberships and Honors

National Merit Scholarship of Government of India
Member, International Society of Magnetic Resonance in Medicine
Member, Osteoarthritis Research Society International
Member, Graduate group, Department of Biochemistry and Molecular Biophysics, University of Pennsylvania
Member and Chairman of graduate thesis committees, Department of Biochemistry and Molecular Biophysics, University of Pennsylvania
Member, Graduate group, Department of Bioengineering, University of Pennsylvania
Referee, Journal of Magnetic Resonance
Referee, Magnetic Resonance in Medicine

Recent Work

Research Interests

My research interests are In developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for early diagnosis and quantification of physiological and functional parameters in pathologies such as arthritis, stroke, cancer and Alzheimer’s Disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection and spin locking for studying molecular dynamics in biological tissues in vivo. In particular, sodium and spin-locking MRI are targeting to map proteoglycan molecules (e.g. Aggrecan) in the connective tissues in vivo. Indirect 17O MRI is aimed at studying cerebral blood flow and cerebral oxidative metabolism and tumor perfusion and metabolism. Spin-locking MRI is being developed to impart novel contrast in various tissue types (brain, connective tissues and tumors), macromolecular ordering in tissues, and visualize and quantify Amyloidal plaques in Alzheimer’s disease in vivo.

Teaching Interests

Director of two graduate level courses (BMB 601 and BMB 603) offered by the Biochemistry and Molecular Biophysics graduate group of the Biomedical Graduate Studies program of the University of Pennsylvania School of Medicine.

Research Support

These research activities are being supported by multiple NIH grants from NIAMS, NIBIB, NINDS, NCRR, NCI, the Arthritis foundation, the Whitaker foundation, the Dana Foundation, GSK, the University Research Foundation, and the McCabe foundation.

Publications

  • Eric A. Mellon, Shashank Beesam R, Elliott M, Reddy R. Mapping of Cerebral Oxidative Metabolsim with MRI. Proceedings of the National Academy of Sciences of the United States of America, 107(26): 11787-11792, (2010).
  • Li LZ. Zhou R. Xu HN. Moon L. Zhong T. Kim EJ. Qiao H. Reddy R. Leeper D. Chance B. Glickson JD Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential, Proceedings of the National Academy of Sciences of the United States of America. 106(16): 6608-13, (2009), PMC2672511.
  • Witschey WR, Borthakur A, Elliott MA, Magland J, McArdle EL, Wheaton A, Reddy R. Spin-locked balanced steady-state free-precession (slSSFP). Magn Reson Med. 2009 Oct; 62(4): 993-1001, PMC2859035.
  • Mellon EA. Pilkinton DT. Clark CM. Elliott MA. Witschey WR 2nd. Borthakur A. Reddy R. Sodium MR imaging detection of mild Alzheimer disease: preliminary study. American Journal of Neuroradiology 30(5): 978-84, 2009, PMCID: 2866317.
  • Mellon EA, Lee SC, Pickup S, Kim S, Goldstein SC, Floyd TF, Poptani H, Delikatny EJ, Reddy R and, Glickson JD Detection of Lactate with a hadamard slice selected, selective MQC, chemical shift imaging sequence on a clinical MRI scanner: Application to tumors and muscle ischemia, Magn. Reson Med. 62(6): 1404-1413, 2009, PMID: 19785016.
  • Mellon EA. Beesam RS. Baumgardner JE. Borthakur A. Witschey WR 2nd. Reddy R. Estimation of the regional cerebral metabolic rate of oxygen consumption with proton detected 17O MRI during precision 17O2 inhalation in swine. Journal of Neuroscience Methods 179(1): 29-39, 2009, PMC2680754.
  • Mellon EA. Beesam RS. Kasam M. Baumgardner JE. Borthakur A. Witschey WR Jr. Reddy R. Single shot T1rho magnetic resonance imaging of metabolically generated water in vivo, Advances in Experimental Medicine & Biology 645: 279-86, 2009, PMID: 19227483.
  • Witschey WR, Borthakur A, Elliott MA, Fenty M, Sochor MA, Wang C, Reddy R. T1ρ-prepared balanced gradient echo for rapid 3D T1ρ MRI. J Magn Reson Imaging 2008;28(3):744-754. PMC2593793.
  • Borthakur A, Corbo M, Trojanowski JQ, Lee Virginia MY, Reddy R. In vivo Measurement of Plaque Burden in a Mouse Model of Alzheimer’s Disease, J. Magn. Reson. Imaging 24,1011-7(2006), PMC2859034.
  • Hulvershorn J, Borthakur A, Bloy L, Gualtieri EE, Reddy R. Leigh JS, Elliott M. T1ρ Contrast in functional magnetic resonance imaging. Magn. Reson. Med. 54, 1155-1162 (2005), PMID: 16217783.
  • Tailor, D. R., Baumgardner, J. E., Regatte, R. R., McLaughlin, A. C., Leigh, J. S., Reddy R. Proton MRI of Metabolically Produced H217O Using an Efficient 17O2 Delivery System, Neuroimage 22, 611(2004), PMID: 15193589.
  • Wheaton AJ, Borthakur A, Corbi MT, Moonis G, Melhem E, Reddy R. T2rho contrast in MR images of the human brain. Magn Reson Med. 52, 1223-1227 (2004), PMID: 15562499.
  • Tailor, D. R., Poptani, H., Glickson, J. D., Leigh, J. S., Reddy, R., High-Resolution Assessment of Blood Flow in Murine RIF-1 Tumors by Monitoring Uptake of H217O With Proton T1ρ-Weighted Imaging, Magn. Reson. Med., 49, 1-6 (2003), PMID: 12509813.
  • Tailor, D. R., Roy, A., Regatte, R. R., Charagundla, S. R., McLaughlin, A. C., Leigh, J. S., Reddy R. Indirect 17O-Magnetic Resonance Imaging of Cerebral Blood Flow in the Rat, Magn. Reson. Med. 49, 479-487 (2003), PMID: 12594750.
  • Duvvuri U, Goldberg AD, Kranz JK, Hoang L, Reddy R, Wehrli FW, Wand AJ, Englander SW, Leigh JS. Water magnetic relaxation dispersion in biological systems: the contribution of proton exchange and implications for the noninvasive detection of cartilage degradation. Proc Natl Acad Sci U S A 2001;98(22):12479-12484, PMC60079.

Visit the Lab's website for more details about its research activities, recent developments, memebers, and a list of publications.

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