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Professor, Department of Radiology, Director, CMROI
Contents |
Contact
Tel: 215-898-5708
Fax: 215-573-2113
email: ravi@mail.mmrrcc.upenn.edu
Education
| Ph.D. | 1989 | Indian Institute of Technology, Kanpur (Chemistry) |
| M.Sc. | 1982 | Kakatiya University, Warangal (Chemistry) |
| B.Sc. | 1979 | Osmania University, Hyderabad (Chemistry) |
Positions and Employment
| 1988-1989 | Research Assistant | IIT, Kanpur | |
| 1989-1992 | Post-Doctoral Fellow | Dept. of Biochem/Biophysics | UPenn |
| 1992-1993 | Research Associate | Dept. of Radiology | UPenn |
| 1993-1995 | Technical Director | MMRRCC | UPenn |
| 1994-2000 | Research Assist. Professor | Dept. of Radiology | UPenn |
| 2000-2006 | Associate Prof. of Radiology | Dept. of Radiology | UPenn |
| 2006- | Prof. of Radiology | Dept. of Radiology | UPenn |
| 2007- | Director, CMROI | Dept. of Radiology | UPenn |
Professional Memberships and Honors
| National Merit Scholarship of Government of India |
| Member, International Society of Magnetic Resonance in Medicine |
| Member, Osteoarthritis Research Society International |
| Member, Graduate group, Department of Biochemistry and Molecular Biophysics, University of Pennsylvania |
| Member and Chairman of graduate thesis committees, Department of Biochemistry and Molecular Biophysics, University of Pennsylvania |
| Member, Graduate group, Department of Bioengineering, University of Pennsylvania |
| Referee, Journal of Magnetic Resonance |
| Referee, Magnetic Resonance in Medicine |
Recent Work
Research Interests
My research interests are In developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for early diagnosis and quantification of physiological and functional parameters in pathologies such as arthritis, stroke, cancer and Alzheimer’s Disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection and spin locking for studying molecular dynamics in biological tissues in vivo. In particular, sodium and spin-locking MRI are targeting to map proteoglycan molecules (e.g. Aggrecan) in the connective tissues in vivo. Indirect 17O MRI is aimed at studying cerebral blood flow and cerebral oxidative metabolism and tumor perfusion and metabolism. Spin-locking MRI is being developed to impart novel contrast in various tissue types (brain, connective tissues and tumors), macromolecular ordering in tissues, and visualize and quantify Amyloidal plaques in Alzheimer’s disease in vivo.
Teaching Interests
Director of two graduate level courses (BMB 601 and BMB 603) offered by the Biochemistry and Molecular Biophysics graduate group of the Biomedical Graduate Studies program of the University of Pennsylvania School of Medicine.
Research Support
These research activities are being supported by multiple NIH grants from NIAMS, NIBIB, NINDS, NCRR, NCI, the Arthritis foundation, the Whitaker foundation, the Dana Foundation, GSK, the University Research Foundation, and the McCabe foundation.
Visit the Lab's website for more details about its research activities, recent developments, memebers, and a list of publications.
