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Contents 1 SequenceTree 2 Patents 3 T1ρ MRI Pulse Sequences 4 Multi-nuclear imaging and Spectroscopy 5 Radial Imaging / KWIC Reconstruction 6 ASL Pulse Sequence 7 Hyperpolarized Imaging 8 Optical Imaging Dissemination

SequenceTree

SequenceTree is an open-source pulse programming environment with a large user community which is growing every day.

Many pulse sequences are available for download, including:

Spoiled Gradient Echo, Balanced Gradient Echo, Fast Spin Echo, Diffusion, T_1ρ.

To learn more about SequenceTree or join the SequenceTree community, visit thesouthpoles.com/sequencetree

Patents

Brief list of patents awarded between 2004-2008

• Reddy, Ravinder; Charagundla, Sridhar R.; Borthakur, Ari; Shapiro, Erik M. ||Pulse imaging sequences and methods for T1p-weighted MRI|| U.S. Patent No. 6,836,114|| December 28, 2004.

• Rizi, Rahim, Baumgardner, J., Roberts, D., Schnall, M.D., Lipson, D., Quantitative pulmonary imaging, U.S. Patent No. 6,915,151, July 5, 2005.

• Yodh; Arjun G.; Greenberg; Joel H.; Yu; Guoqiang; Detre; John A. ; Durduran; Turgut; Burnett; Mark G.; Mohler; Emile R. III; Quon; Harry; Hahn; Stephen M. Optical measurement of tissue blood flow, hemodynamics and oxygenation, U.S. Patent Application No. 20060063995, March 23, 2006.

• Dougherty, Larry; Song, Hee Kwon; Boston, Raymond C.; Schnall, Mitchell. Rapid 3-Dimensional Bilateral MR Imaging, Patent Application No. 60/793,799, April 21, 2006.

• Yodh; ArjunG ; Islam; MohammadF; Ali; Ahmed M.Alsayed. Carbon nanotubes: high solids dispersions and nematic gels thereof, U.S. Patent Application No. 20060099135, May 11, 2006.

• Yodh; Arjun G.; Islam; Mohammad F.; Johnson; Alan T. JR.; Johnston; Danvers E. Process and applications of carbon nanotube dispersions, U.S. Patent Application No. 20060115640, June 1, 2006.

• Rizi, Rahim, Baumgardner, J., Roberts, D., Schnall, M.D., Lipson, D. Equilibration method for high resolution imaging of lung compliance and distribution of functional residual capacity, U.S. Patent No. 7,072,706, July 4, 2006.

• Reddy, Ravinder; Borthakur, Ari; Wheaton, Andrew J.; Charagundla, Sridhar R. Reduced specific absorption ratio T1p-weighted MRI, U.S. Patent No. 7,116,104, October 3, 2006.

• Reddy, Ravinder, Borthakur, Ari, Charagundla, Sridhar, SLIPS: A pulse sequence for fast 3D T1rho MRI, U.S. Patent Application No. 60/852,241, October 17,2006.

• Yodh; Arjun G.; Islam; Mohammad F.; Bryning; Mateusz B. Single wall nanotube composites, U.S. Patent Application No. 20060293434, December 28, 2006.

• Reddy, Ravinder; Borthakur, Ari; Charagundla, Sridhar; Witschey, Walter, A Method for the Simultaneous T1rho and Sodium MRI Mapping of Macromolecules and Tissue Structure, U.S. Patent Application No. 60/923,215, April 11, 2007.

• Hollebeek; Robert J.; Schnall; Mitchell D.; Beckerman; Barbara G.; Payne; Patricia W.; Hammitt; Frank Paul, Cross-enterprise wallplug for connecting internal hospital/clinic imaging systems to external storage and retrieval systems U.S. Patent Application No. 20070083615, April 12, 2007.

• Kadlecek; Steve; Rizi; Rahim. Gaseous nuclear symmetric state and quantification thereof, U.S. Patent Application No. 20080236250, October 2, 2008.

T_1ρ MRI Pulse Sequences

Pulses sequences are available on the following platforms:

Siemens, GE, Philips, and Varian

T_1ρ users group:

Institution	Contact	Use
Calgary Univ	Jeff Dunn Ph.D.	Multiple
CHOP	Diego Jaramillo, M.D.	Spine
Univ. of Iowa	Daniel Thedens Ph.D.	Ankle
Montreal	Gilles Beaudoin Ph.D.	Spine
Univ of Ottawa	Ian Cameron Ph.D.	Knee
Pennsy. Hospital	J. Bruce Kneeland M.D.	Knee
SUNY, Stony Brook	Mark Wagshuk Ph.D.	Spine
Fox Chase Cancer Center	Bart Milestone M.D.	Knee
Univ. of Pittsburgh	C. Kent Kwoh M.D.	Knee
Thomas Jeff. Univ	Alex Dresner Ph.D.	Knee
Penn State	Tim Mosher M.D.	Knee
Brown Univ.	Edward Walsh Ph.D.	Neuroscience
Rhode Island Hosp.	Glenn Tung M.D.	Neuroscience
Univ. of Maryland	Rao Gullapali M.D.	Multiple
Univ. of Wisconsin	Richard Kojowski M.D.	Spine
Campus Bio-Medico, Rome	Vincenzo Denaro M.D.	Spine
NYU	Ravi Regatte Ph.D.	Knee
Tan Tock Seng Hosp., Singapore	Seng Choe Tham M.D.	Spine
Mallinckrodt Inst. of Radiology	David Loy M.D.	Spine
Royal National Orthopaedic Hosp., UK	Sean Molloy M.D.	Spine

For more information, please contact Ari Borthakur

Multi-nuclear imaging and Spectroscopy

Pulses sequences for sodium imaging and spectroscopy on the following platforms:

Siemens, GE, Philips, and Varian

For more information, please contact Ari Borthakur

Radial Imaging / KWIC Reconstruction

1. Fox Chase Cancer Center, Philadelphia, PA. 2. Jefferson University, Philadelphia, PA 3. Hershey Medical Center, Hershey, PA 4. Radium Hospital of Norway, Norway.

ASL Pulse Sequence

ASL users group:

Institution	Contact
University of Minnesota, Minneapolis, MN	Bryon Mueller, MD
Portland Neurovascular, Portland, OR	David Silker, MD
University of Melbourne, Victoria, Australia	Gary Egan, PhD, MBA
University of California, Irvine, CA	Jessica Turner, MD
University of Oregon, Eugene, OR	Jolinda Smith, PhD
Justus-Liebeg Univesity Giessen, Giessen, Germany	Rudolf Stark, Prof. Dr.
University of South Carolina, Columbia, SC	Paul S. Morgan, MD
University Hospital Geneva, Geneva, Switzerland	Magalie Viallon, Doctor in physics
Max Plank Institute, Leipzig, Germany	Harald Moller, Prof. Dr.
University College London, London, UK	Dr. David Thomas
Malmo University Hospital, Malmo, Sweden	Jonas Svennson, PhD
University of Duesseldorf, Duesseldorf, Germany	Hans-Joerg Wittsack, MD
University of Pittsburgh, Pittsburgh, PA	Kwan-Jin Jung, PhD
University of Virginia, Charlottesville, VA	James Coan, PhD
University of Bonn/Life and Brain Bonn, Germany	Dr. med. Knut Schnellko
Hokkaido University Hopital Sapporo, Japan	Kohsuke Kudo, PhD
University of Kansas Medical Center, Kansas City, KS	Paul Terranova, PhD
Nevada Cancer Institute, Las Vegas, NV	H. Michael Gach, PhD
IDAC, Tohoku Univesity, Tohoku, Japan	Tina Rasmussen, PhD
Case Western University, Cleveland, Oh	Jean Tkah, PhD
University of Trento, Trento, Italy	Jorge Jovicich, PhD
University of Oxford, Oxford, UK	Prof. Peter Jezzard of the Chancellor
Massachusetts General Hospital	Ellen Grant
Childrens Hospital, Cincinnati, OH	Kim Cecil
University, Wurzburg
The Mind Institute, University of New Mexico
mory University	Xiaoping Hu
University of Frankfurt
University of California at San Francisco	Norbert Schuff
Montreal Neurological Institute	James Pike
St. Francis Hospital
National Institute on Drug Abuse	Yihong Yang and Elliott Stein
University of Texas Health Science	Jia-hong Gao
University of North Carolina at Chapel Hill	Hongyu An
St Jude Children's Research Hospital
Rochester University	Jianhui Zhong
Tian Tan Hospital, Beijing	Xun Zhang
UCLA, UCDavis	Jeffrey R. Alger and Tony Simon
Ghent University, Belgium
Kyoto University, Japan
Merck & Co., INC	Don Williams
McLean Hospital, Harvard Medical School
Washington University	Kevin Black
Georgetown University	Tom Zeffiro
Wayne State University
Chinese Academy of Science	Yan Zhuo
University of Ulm
Singapore Hospital	Mike Chee
UT Southwest Medical Center at Dallas, Dallas, TX	Richard Briggs, Ph.D.
University Maryland	Rao Gullapalli
Brain Research Institute, Victoria, Australia	Fernando Calamante, M.D.
University of Iowa	Vincent A. Magnotta
niversitätsklinik und Poliklinikfür Psychiatrie Bern	Andrea Federspiel
Center for Applied Medical Research, University of Navarra	Maria A. Fernandez Seara
University Hospital Verona, Verona, Italy	Dr. Francesca Pizzini
Radboud University Nijmegen – Nijmegen, The Netherlands	Prof. David Norris, Ph.D.

Hyperpolarized Imaging

The technology developed under the hyperpolarized imaging core was transferred to 2 sites;

• Johns Hopkins University
• Children’s Hospital of Philadelphia

Optical Imaging Dissemination

1. Diffuse Correlation Spectroscopy
   • Massachusetts General Hospital, David Alan Boas
   • University of Konstanz, Germany, Thomas Gisler
   • University of Irvine, Bruce J Tromberg
   • Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, Reiner Macdonald
   • University of Kentucky, Guoqiang Yu
   • Roswell Park Cancer Institute, Ulas Sunar
   • Nanyang Technological University, Singapore, Kijoon Lee
   • National Yang Min University, Taiwan, Hsing-Wen Wang
2. Diffuse Optical Tomography Reconstruction Software/Algorithms
   • Foundation for Research and Technology, Greece, Jorge Ripoll
   • Nanyang Technological University, Singapore, Kijoon Lee