Research Associate

Joint Appointment: Department of Radiology, Department of Physics and Astronomy

Contact

209 South 33rd Str

Philadelphia, PA 19104

Tel: (215) 898 5148

Fax: (215) 573 6391

e-mail: durduran{at}sas{dot}upenn{dot}edu

web: homepage

Education

Ph.D. 2004, University of Pennsylvania (Physics)

Recent Work

Research Interests

Development of diffuse optical techniques for functional imaging of brain, monitoring of cancer therapies and for cardiovascular diseases effecting the muscles. Theoretical and experimental advancement of diffuse correlation spectroscopy for optical measurement of blood flow in deep tissues. Laser speckle flowmetry of the animal brain.

Professional Experience

05/06­ Present Research Associate, Joint Appt. with Dept. of Physics and Astronomy, U. of Pennsylvania Dept. of Radiology, Hospital of U. of Pennsylvania Member of Metabolic Magnetic Resonance Research and Computing Center (MMRRCC)

11/05­12/05 Guest Scientist with Dr H Wabnitz and Dr R Mcdonald Physikalisch-Technische Bundesanstalt (PTB), Berlin,Germany

09/03­05/06 Postdoctoral Fellow with Dr. A. G. Yodh, Dept. of Physics and Astronomy, U. of Pennsylvania

8/97­9/03 Research Assistant to Dr. A. G. Yodh, Dept. of Physics and Astronomy, U. of Pennsylvania

Publications

A Corlu, R Choe, T Durduran, M A Rosen, M Schweiger, S R Arridge, M D Schnall, and Yodh A G. Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans. Optics Express, 15(11):6696­6716, 2007.

G Yu, T Floyd, T Durduran, C Zhou, J J Wang, J A Detre, and A G Yodh. Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial-spin-labeling perfusion. Opt Exp, 15:1064­75, 2007.

U Sunar, H Quon, T Durduran, J Zhang, J Du, C Zhou, G Yu, R Choe, A Kilger, R Lustig, L Loevner, S Nioka, B Chance, and A G Yodh. Non-invasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study. J Biomed Opt, 11:064021, 2006.

G Yu, T Durduran, C Zhou, T C Zhu, J C Finlay, T M Busch, S B Malkowicz, S M Hahn, and A G Yodh. Real-time in situ monitoring of human prostate photodynamic therapy with diffuse light. Photochem Photobiol, 82:1279­84, 2006.

C Zhou, G Yu, D Furuya, J H Greenberg, A G Yodh, and T Durduran. Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain. Opt. Exp, 14:1125­44, 2006.

R Choe, A Corlu, K Lee, T Durduran, S D Konecky, M Grosicka-Koptyra, S R Arridge, B J Czerniecki, D L Fraker, A DeMichele, B Chance, M A Rosen, and A G Yodh. Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI. Med. Phys., 32:1128­39, 2005.

A Corlu, R Choe, T Durduran, K Lee, M Schweiger, E M C Hillman, S R Arridge, and A G Yodh. Diffuse optical tomography with spectral constraints and wavelength optimization. Appl Opt, 44:2082­93, 2005.

T Durduran, R Choe, G Yu, C Zhou, J C Tchou, B J Czerniecki, and A G Yodh. Diffuse optical measurement of blood flow in breast tumors. Opt Lett, 30:2915­17, November 2005.

G Yu, T Durduran, G Lech, C Zhou, B Chance, E R Mohler, and A G Yodh. Time-dependent blood flow and oxygenation in human skeletal muscle measured with noninvasive near-infrared diffuse optical spectroscopies. J Biomed Opt, 10(3):024027­1­12, 2005.

G Yu, T Durduran, C Zhou, H W Wang, M E Putt, M Saunders, C M Seghal, E Glatstein, A G Yodh, and T M Busch. Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy. Clin Cancer Res, 11:3543­3552, 2005.

T Durduran. Noninvasive measurements of tissue hemodynamics with hybrid diffuse optical methods. Med Phys, 31:2178, 2004. T Durduran, M G Burnett, G Yu, C Zhou, D Furuya, A G Yodh, J A Detre, and J H Greenberg. Spatio-temporal quantification of cerebral blood flow during functional activation in rat somatosensory cortex using laser speckle flowmetry. J. Cereb. Blood Flow Metab., 24:518­525, 2004.

T Durduran, G Yu, M G Burnett, J A Detre, J H Greenberg, J Wang, C Zhou, and A G Yodh. Diffuse optical measurements of blood flow, blood oxygenation and metabolism in human brain during sensorimotor cortex activation. Opt Lett, 29:1766­1768, 2004.

R Choe, T Durduran, G Q Yu, M J M Nijland, B Chance, A G Yodh, and N Ramanujam. Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero. Proc Natl Acad Sci USA, 100:12950­12954, 2003.

A Corlu, T Durduran, R Choe, M Schweiger, E M C Hillman, S R Arridge, and A G Yodh. Uniqueness and wavelength optimization in continous-wave multispectral diffuse optical tomography. Opt. Lett, 28:2339­2341, 2003.

J P Culver, R Choe, M J Holboke, L Zubkov, T Durduran, A Slemp, V Ntziachristos, D N Pattanayak, B Chance, and A G Yodh. 3D diffuse optical tomography in the plane parallel transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging. Med Phys, 30:235­247, 2003.

J P Culver, T Durduran, D Furuya, C Cheung, J H Greenberg, and A G Yodh. Diffuse optical tomography of cerebral blood flow, oxygenation and metabolism in rat during focal ischemia. J. Cereb. Blood Flow Metab., 23:911­24, 2003.

G Yu, T Durduran, D Furuya, J H Greenberg, and A G Yodh. Frequency-domain multiplexing system for in vivo diffuse light measurements of rapid cerebral hemodynamics. Appl. Opt., 42:2931­39, 2003.

J P Culver, T Durduran, D Furuya, C Cheung, J H Greenberg, and A G Yodh. Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest. Adv. Exp. Biol., XXIII:293­298, 2002.

T Durduran, R Choe, J P Culver, L Zubkov, M J Holboke, J Giammarco, B Chance, and A G Yodh. Bulk optical properties of healthy female breast tissue. Phys Med Biol, 47:2847­2861, 2002.

X D Li, D N Pattanayak, T Durduran, J P Culver, B Chance, and A G Yodh. Near-field diffraction tomography with diffuse photon density waves. Phys Rev E, 61(4):4295­4309, 2000.

T Durduran, J P Culver, M J Holboke, X D Li, L Zubkov, B Chance, D N Pattanayak, and A G Yodh. Algorithms for 3d localization and imaging using near-field diffraction tomography with diffuse light. Optics Express, 4(8):247­262, 1999.

Q. Zhu, T Durduran., V. Ntziachristos, M. Holboke, and A. G. Yodh. Imager that combines near-infrared diffusive light and ultrasound. Opt Lett, 24(15):1050­1052, 1999.

X D Li, T Durduran, B Chance, A G Yodh, and D N Pattanayak. Diffraction tomography for biochemical imaging with diffuse-photon density waves. Opt Lett, 22(8):573­575, 1997.

T Durduran, B Chance, A G Yodh, and D A Boas. Does the photon diffusion coefficient depend on absorption? J. Opt. Soc. Am. A, 14:3358­3365, 1997.